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Expression data from 43 Ovarian tumors

ABSTRACT: Gene expression profiles of malignant carcinomas surgically removed from ovarian cancer patients pre-treated with chemotherapy (neo-adjuvant) prior to surgery group into two distinct clusters. One group clusters with carcinomas from patients not pre-treated with chemotherapy prior to surgery (C-L) while the other clusters with non-malignant adenomas (A-L). Although the C-L cluster is preferentially associated with p53 loss-of-function (LOF) mutations, the C-L cluster cancer patients display a more favorable clinical response to chemotherapy as evidenced by enhanced long-term survivorships. Keywords: Patient Tumor Samples

ORGANISM(S): Homo sapiens

PROVIDER: GSE7463 | GEO | 2007/05/31

SECONDARY ACCESSION(S): PRJNA100209

REPOSITORIES: GEO

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