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X chromosome cDNA microarray screen of lymphoblasts from males with XLMR

ABSTRACT: The goal of this study is to identify genes that show altered transcript levels in lymphoblasts from male patients with XLMR as candidate genes that are responsible for XLMR. Keywords: disease state

ORGANISM(S): Homo sapiens

PROVIDER: GSE7470 | GEO | 2007/04/10

SECONDARY ACCESSION(S): PRJNA100271

REPOSITORIES: GEO

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X chromosome cDNA microarray screen of lymphoblasts from males with XLMR

Project description:The goal of this study is to identify genes that show altered transcript levels in lymphoblasts from male patients with XLMR as candidate genes that are responsible for XLMR. Keywords: disease state Using a custom X chromosome cDNA microarray, we studied X chromosome gene expression in lymphoblasts from 43 patients with XLMR and identified those genes with altered transcript levels as compared to that in 6 normal controls.

2010-06-11 | E-GEOD-7470 | biostudies-arrayexpress

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Homo sapiens

Project description:X chromosome cDNA microarray screen of lymphoblasts from males with XLMR

| PRJNA100271 | ENA

Lymphoblasts from healthy individuals vs. individuals with FPD-AML (familial platelet disorder - acute myeloid leukemia)

Project description:RNA derived from lymphoblasts from individuals with FPD-AML is compared to that from related unaffected individuals. Keywords: other

2005-12-01 | GSE2594 | GEO

X chromosome-specific Array-CGH of XLMR patient

Project description:Mental retardation (MR) is a non-progressive cognitive impairment affecting 2 to 3% of the Western population. So far, point mutations and subtle deletions and insertions have been shown to represent only a proportion (<40%) of genetic causes underlying X-linked mental retardation (XLMR). We have screened a subset of 300 presumable X-linked families by X chromosome-specific array-CGH and identified 6 families with overlapping microduplications at Xp11.22 containing two candidate genes; both of which showed overexpression in the affected individuals. Array-CGH data revealed aberrant Cy5/Cy3 log2 ratios for different but overlapping sets of clones indicating varying sizes of these duplications in the different families. Keywords: comparative genomic hybridization

2008-02-20 | GSE9143 | GEO

Lymphoblasts from healthy individuals vs. individuals with FPD-AML (familial platelet disorder - acute myeloid leukemia)

Project description:RNA derived from lymphoblasts from individuals with FPD-AML is compared to that from related unaffected individuals.

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Comparison of the MHC I immunopeptidome repertoire of B-cell lymphoblasts using two isolation methods

Project description:Significant technological advances in both affinity chromatography and mass spectrometry have facilitated the identification of peptides associated with the major histocompatibility complex class I (MHC I) molecules, and enabled a greater understanding of the dynamic nature of the immunopeptidome of normal and neoplastic cells. While the isolation of MHC I-associated peptides (MIPs) typically used mild acid elution (MAE) or immunoprecipitation (IP), limited information currently exists regarding their respective analytical merits. Here, we present a comparison of these approaches for the isolation of two different B-cell lymphoblasts cell models, and report on the recovery, reproducibility, scalability and complementarity of identification from each method. Both approaches yielded reproducible datasets for peptide extracts obtained from 2 to 100 million cells, with 2016 to 5093 MIPs, respectively. The IP typically provides up to 6.4 fold increase in MIPs compared to the MAE. We extended the comprehensiveness of these immunopeptidome analyses using personalized genomic database of B-cell lymphoblasts, and discovered that 0.4 % of their respective MIP repertoire harbored non-synonymous single nucleotide variations (also known as minor histocompatibility antigens, MiHAs).

2018-03-09 | PXD007935 | Pride

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