Genomics

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Single Cell Expression Profiling Resolves the Transcriptional Programs of Early Mesoderm Diversification


ABSTRACT: We analyzed 1,205 cells from the epiblast and nascent mesoderm of gastrulating mouse embryos by single cell RNA-seq, representing the first transcriptome-wide in vivo view of mammalian gastrulation. Based on the distribution of key marker genes and their spatiotemporal expression patterns within the embryo, we identified 10 cell clusters corresponding to the epiblast and developing mesodermal populations. This enabled us to explore the global gene expression dynamics associated with the induction of Brachyury, anterior-posterior patterning of the primitive streak and the earliest stages of blood development.

ORGANISM(S): Mus musculus

PROVIDER: GSE74994 | GEO | 2016/07/07

SECONDARY ACCESSION(S): PRJNA302149

REPOSITORIES: GEO

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