Transcriptomics

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Gene expression changes in anti-FcgRIIb treated DCs and monocytes


ABSTRACT: The ability of dendritic cells (DCs) to activate immunity is linked to their maturation status. In prior studies we have shown that selective antibody-mediated blockade of inhibitory FcgRIIB receptor on human DCs in the presence of activating immunoglobulin (Ig) ligands leads to DC maturation and enhanced immunity to antibody-coated tumor cells. Here we show that Fcg receptor (FcgR) mediated activation of human monocytes and monocyte-derived DCs is associated with a distinct gene expression pattern, including several inflammation associated chemokines as well as type 1 interferon (IFN) response genes including the activation of signal transducer and activator of transcription 1 (STAT1). Keywords: response to antibody

ORGANISM(S): Homo sapiens

PROVIDER: GSE7509 | GEO | 2007/04/30

SECONDARY ACCESSION(S): PRJNA100469

REPOSITORIES: GEO

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