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The SPOP-containing Complex Functions as an E3 Ligase for SETD2 to Regulate Gene-Specific H3K36me3-Coupled Alternative Splicing

ABSTRACT: H3K36me3 has been reported to associate with active gene expression, and SETD2 is the mainly methyltransferase for H3K36me3. We identified SPOP which is a CUL3 family protein as a E3 ligase for SETD2. Genome wide analysis by using ChIPSeq and RNASeq demonstrate that SPOP specificly eliminate H3K36me3 modification at target genes and resulted in alternative splicing of those target genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE75270 | GEO | 2016/11/10

SECONDARY ACCESSION(S): PRJNA303041

REPOSITORIES: GEO

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