The role of Hoxa9 and Meis1 in development of acute myeloid leukemia (mRNA)
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ABSTRACT: OBJECTIVE: MEIS1, a HOX cofactor, collaborates with multiple HOX proteins, such as HOXA9, to accelerate the onset of acute myeloid leukemia (AML) through largely unknown molecular mechanisms. To further resolve these mechanisms, we conducted a structure-function analysis of Meis1 and gene expression profiling, in the context of Hoxa9 leukemogenesis. RESULTS: We show, in a murine bone marrow transplantation model, that the homeodomain of Meis1 is required for leukemogenic collaboration with Hoxa9. Gene expression profiling of a Hoxa9 preleukemic cell line transduced with wild-type or Meis1 homeodomain mutant reveal deregulation of multiple genes including a set not previously implicated as Meis1 targets.
ORGANISM(S): Mus musculus
PROVIDER: GSE75272 | GEO | 2016/09/01
SECONDARY ACCESSION(S): PRJNA302931
REPOSITORIES: GEO
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