Transcriptomics

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Expression data from tumors generated from genome-engineered mice


ABSTRACT: Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations are found in 30–40% of human colorectal cancers (CRC). However, specific therapeutics against KRAS-mutated CRC have not been established. We have previously reported mouse models for colon cancer with and without Kras mutations (CDX2P-G22Cre;Apcflox/flox; KrasG12D and CDX2P-G22Cre;Apcflox/flox mice, respectively). Herein, we aimed to identify candidate genes as novel therapeutic targets or biomarkers for KRAS-mutated CRC by comparing the gene expression profiles of these two mouse models.

ORGANISM(S): Mus musculus

PROVIDER: GSE75435 | GEO | 2015/12/25

SECONDARY ACCESSION(S): PRJNA304298

REPOSITORIES: GEO

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