Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Biphasic GISTs reveal the early mechanisms in GIST high-grade transformation

ABSTRACT: To study the very early changes in high-grade transformation of gastrointestinal stromal tumors (GISTs), 17 biphasic GISTs, with a transitional status in which low-grade and high-grade parts coexist, were collected from 263 continuous cases (6.5%). Nucleic acids of each part were retrieved for gene expression profiling.

ORGANISM(S): Homo sapiens

PROVIDER: GSE75479 | GEO | 2015/12/01

SECONDARY ACCESSION(S): PRJNA304407

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

miRNA expression signatures in gastrointestinal stromal tumors (GISTs)

Project description:To clarify the microRNA (miRNA) expression signatures in gastrointestinal stromal tumors (GISTs), a series of 32 GIST specimens were analyzed using Agilent miRNA microarray V3. Unsupervised hierarchical clustering revealed that GISTs can be categorized into 2 groups according to the expression of a miRNA cluster encoded on chromosome 14q32.31. Total RNA was extracted from 32 fresh frozen GIST specimens obtained from surgical resections. Expression of 851 miRNAs was analyzed using Human miRNA Microarray V3 (Rel 12.0 G4470C; Agilent technologies, Santa Clara, CA, USA). Risk grade was assessed according to the risk definition system proposed by Fletcher et al. (Hum Pathol. 2002;33:459-65.)

2011-11-01 | E-GEOD-31741 | biostudies-arrayexpress

Gene expression signatures in gastrointestinal stromal tumors (GISTs)

Project description:To analyze the gene expression signatures in gastrointestinal stromal tumors (GISTs), a series of 14 GIST specimens were analyzed using Agilent Whole Human Genome Microarray (4x44K, G4112F). Total RNA was extracted from 32 fresh frozen GIST specimens obtained from surgical resections. Gene expression was analyzed using Agilent Whole Human Genome Microarray (4x44K, G4112F, Agilent technologies, Santa Clara, CA, USA). Risk grade was assessed according to the risk definition system proposed by Fletcher et al. (Hum Pathol. 2002;33:459-65.)

2011-11-01 | E-GEOD-31802 | biostudies-arrayexpress

Affymetrix Cytoscan HD 2,600K SNP array data for 9 GISTs

Project description:KIT, PDGFRA, NF1, and SDH mutations are alternate initiating events, fostering hyperplasia in gastrointestinal stromal tumors (GISTs), and additional genetic alterations are required for progression to malignancy. The most frequent secondary alteration, demonstrated in ~70% of GISTs, is chromosome 14q deletion. Here we report hemizygous or homozygous inactivating mutations of the chromosome 14q MAX gene in 16 of 76 GISTs (21%). We find MAX mutations in 17% and 50% of sporadic and NF1-syndromic GISTs, respectively, and we find loss of MAX protein expression in 48% and 90% of sporadic and NF1-syndromic GISTs, and in 3 of 8 micro GISTs, which are early GISTs. MAX genomic inactivation is associated with p16 silencing in the absence of p16 coding sequence deletion, and MAX induction restores p16 expression and inhibits GIST proliferation. Hence, MAX inactivation is a common event in GIST progression, fostering cell cycle activity in early GISTs.

2017-02-03 | GSE93077 | GEO

Gene expression signatures in gastric gastrointestinal stromal tumors (GISTs)

Project description:To explore mechanisms underlying wild-type GISTs, gene expression analysis was performed on 15 gastric GISTs.

2013-06-14 | GSE47911 | GEO

Homo sapiens

Project description:Biphasic GISTs reveal the early mechanisms in GIST high-grade transformation

| PRJNA304407 | ENA

Array CGH analysis in gastric gastrointestinal stromal tumors (GISTs)

Project description:To explore mechanisms underlying wild-type GISTs, array CGH was performed on 32 gastric GISTs (4 risk groups stratified by tumor size and mitotic counts comprised 8 cases each).

2013-06-14 | GSE47912 | GEO

miRNA Expression in PDGFRA Mutant GISTs

Project description:Context: Gastrointestinal stromal tumors (GISTs) harboring mutations in the PDGFRA gene occur in only about 5–7% of patients. The most common PDGFRA mutation is exon 18 D842V, which is corre-lated with specific clinico-pathological features compared to the other PDGFRA mutated GISTs. Herein, we present a miRNA expression profile comparison of PDGFRA D842V mutant GISTs and PDGFRA with mutations other than D842V (non-D842V). miRNA expression profiling was carried out on 10 patients using a TLDA miRNA array. Then, miRNA expression was followed by bioinformatic analysis aimed at evaluating differential expression, pathway enrichment, and miRNA-mRNA networks. We highlighted 24 differentially expressed miRNAs between D842V and non-D842V GIST patients. Pathway enrichment analysis showed that deregulated miRNAs targeted genes that are mainly involved in the immune response pathways. The miRNA-mRNA networks highlighted a signature of miRNAs/mRNA that could explain the indolent behavior of the D842V mutated GIST. The results highlighted a different miRNA fingerprint in PDGFRA D842V GISTs compared to non-D842Vmutated patients, which could explain the different bio-logical behavior of this GIST subset.

2022-10-31 | GSE215402 | GEO

Gene expression signatures in gastric gastrointestinal stromal tumors (GISTs)

Project description:To explore mechanisms underlying wild-type GISTs, gene expression analysis was performed on 15 gastric GISTs. 11 KIT-mutant, 1 PDGFRA-mutant and 3 wild-type GISTs

2013-06-14 | E-GEOD-47911 | biostudies-arrayexpress

miRNA expression signatures in gastrointestinal stromal tumors (GISTs)

2011-11-01 | GSE31741 | GEO

Array CGH analysis in gastric gastrointestinal stromal tumors (GISTs)

2013-06-14 | E-GEOD-47912 | biostudies-arrayexpress