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Gene expression in mouse tissues in response to short-term calorie restriction

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE75574 | GEO | 2017/05/31

SECONDARY ACCESSION(S): PRJNA304621

REPOSITORIES: GEO

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Gene expression in mouse heart in response to short-term calorie restriction

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Gene expression in mouse liver in response to short-term calorie restriction

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Gene expression in mouse liver in response to short-term calorie restriction

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Gene expression in mouse gastrocnemius muscle in response to short-term calorie restriction

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Gene expression in mouse tissues in response to short-term calorie restriction

Project description:Gene expression in mouse tissues in response to short-term calorie restriction

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Comparison of the long-term effects of calorie restriction without malnutrition on global gene expression profiles of rat and human skeletal muscle

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Gene expression in mouse epididymal white adipose tissue in response to short-term calorie restriction

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2017-05-31 | GSE75573 | GEO

Short-term calorie restriction enhances skeletal muscle stem cell function.

Project description:Calorie restriction (CR) extends life span and ameliorates age-related pathologies in most species studied, yet the mechanisms underlying these effects remain unclear. Using mouse skeletal muscle as a model, we show that CR acts in part by enhancing the function of tissue-specific stem cells. Even short-term CR significantly enhanced stem cell availability and activity in the muscle of young and old animals, in concert with an increase in mitochondrial abundance and induction of conserved metabolic and longevity regulators. Moreover, CR enhanced endogenous muscle repair and CR initiated in either donor or recipient animals improved the contribution of donor cells to regenerating muscle after transplant. These studies indicate that metabolic factors play a critical role in regulating stem cell function and that this regulation can influence the efficacy of recovery from injury and the engraftment of transplanted cells.

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The effects of graded levels of calorie restriction: IV. Non-linear change in behavioural phenotype of mice in response to short-term calorie restriction.

Project description:Animals have to adjust their activities when faced with caloric restriction (CR) to deal with reduced energy intake. If CR is pronounced, allostasis can push individuals into alternate physiological states which can result in important health benefits across a wide range of taxa. Here we developed a new approach to determine the changes in behavioural phenotype associated with different levels of CR. We exposed C57BL/6 male mice to graded CR (from 0 to 40%) for three months and defined their behavioural phenotype using hidden Markov models of their movement and body temperature. All 40% CR mice exhibited a state-shift in behavioural phenotype and only some exposed to 30% CR did. We show for the first time that mice changed their activity characteristics rather than changed their activities. This new phenotyping approach provides an avenue to determine the mechanisms linking CR to healthspan.

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