Transcriptomics

Dataset Information

0

MiRNA-1343 attenuates pathways of fibrosis by targeting the TGF-beta receptors [RNA-seq]


ABSTRACT: miRNA-1343 is an uncharacterized miRNA predicted to target a number of genes involved in epithelial cell function including TGF-beta signaling, cell adhesion, and cell proliferation. We transiently overexpressed miRNA-1343 or a non-targeting control miRNA in A549 and 16HBE14o- human airway cell lines. As predicted, RNA-seq following miRNA-1343 overexpression showed significant downregulation of genes involved in these pathways. Furthermore, genes involved in cholesterol and lipid biosynthesis were found to be significantly upregulated by miRNA-1343 overexpression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE75591 | GEO | 2016/03/03

SECONDARY ACCESSION(S): PRJNA304643

REPOSITORIES: GEO

Similar Datasets

2013-10-02 | E-MEXP-3986 | biostudies-arrayexpress
| S-EPMC5540775 | biostudies-literature
| S-EPMC4867233 | biostudies-literature
2017-10-16 | GSE99209 | GEO
2018-03-20 | GSE96757 | GEO
2018-01-03 | GSE101829 | GEO
2013-10-30 | E-GEOD-51828 | biostudies-arrayexpress
| PRJNA395614 | ENA
2023-06-07 | GSE220853 | GEO
2023-06-07 | GSE220852 | GEO