Transcriptomics

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Transcriptome profiling of genetically modified P. falciparum parasite strains with distinct drug resistance phenotypes


ABSTRACT: We compared the transcriptomic profiles between P. falciparum strains displaying mutant or wild-type pfcrt or varying in pfcrt or pfmdr1 expression levels All values were normalized using a background pool constituted of 11 transcriptome data sets that constituted a baseline for gene expression fold change and gene set enrichment. In addition to that reported in the present study, the pool included two IDC transcriptome data sets generated for Dd2 parasites pressured long-term with pulses of dihydroartemisinin (the 3b1 line) and the non-pressured parent (Lisewski et al., Cell, 2014), as well as the transcriptome data set previously reported for the 3D7, Dd2 and HB3 strains (Bozdech et al., PLos Biol 2003, Llinas et al, NAR 2006)

ORGANISM(S): Plasmodium falciparum

PROVIDER: GSE75807 | GEO | 2015/12/09

SECONDARY ACCESSION(S): PRJNA305412

REPOSITORIES: GEO

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