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DYRK2 regulates cancer stem cell population.

ABSTRACT: We used microarrays to identified new factor that regulates cancer stem cell population in shRNA DYRK2 cells using stable DYRK2 knockdown cells and mammosphere.

ORGANISM(S): Homo sapiens

PROVIDER: GSE75918 | GEO | 2016/08/23

SECONDARY ACCESSION(S): PRJNA305706

REPOSITORIES: GEO

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DYRK2 regulates cancer stem cell population.

Project description:We used microarrays to identified new factor that regulates cancer stem cell population in shRNA DYRK2 cells using stable DYRK2 knockdown cells and mammosphere. We stably silenced DYRK2 in MCF-7 cells (shRNA-DYRK2 cells) using pSuper vector. For control, pSuper control cells were created. We obtained expression profiles from shRNA-DYRK2 cells and pSuper control cells. We also obtained RNA from mammosphere which are stably expressing pSuper vector or shRNA DYRK2.

2016-08-23 | E-GEOD-75918 | biostudies-arrayexpress

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Project description:RRP1B is a Metastasis Modifier that Regulates the Transcriptome through mRNA Splicing To assess the role of RRP1B in alternative mRNA splicing, we knocked down the expression of Rrp1b in the highly metastatic mouse mammary tumor cell line Mvt-1 using shRNA. Two control and two knockdown stable cell lines were selected for RNA-sequencing.

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Project description:DYRK2 regulates cancer stem cell population.

| PRJNA305706 | ENA

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