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ZCF32, a fungus specific Zn(II)2-Cys6 transcription factor, is a major regulator of the biofilm circuit in the human pathogen Candida albicans

ABSTRACT: To delineate the functional role of ZCF32 in Candida albicans biology, we carried out the genome wide expression analysis of wild-type and zcf32 null mutants by global expression array. We analysed the gene expression profiles of YPK102/1 and YPK102/2 and the parent wild type (SC5314) strain grown in YPD liquid medium at 30°C till the start of the stationary phase. In the microarray analysis, a total of 607 genes were found to be differentially expressed (fold change < 1.5 at p-value < 0.05) between the wild type and two zcf32 null mutants. Out of the 607 differentially expressed genes, 438 genes were up-regulated whereas 169 genes were down-regulated. Gene ontology (GO) analysis of up-regulated and down-regulated genes suggests that biofilm, filamentation, iron homeostasis, cell wall biogenesis, oxidation, and cell cycle are the major pathways altered in zcf32 null mutant.

ORGANISM(S): Candida albicans

PROVIDER: GSE76165 | GEO | 2016/12/31

SECONDARY ACCESSION(S): PRJNA306506

REPOSITORIES: GEO

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