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Cell type-specific alternative splicing of cytoskeletal domains governs cell fate in the developing cerebral cortex

ABSTRACT: Alternative splicing regulates over 90% of multiexon mammlian genes, but its role in specifying neural progenitor cell (NPC) fates has not been explored. Our analyses of purified mouse NPCs and neurons from developing cerebral cortices revealed hundreds of conserved and differentially spliced exons that add or remove key protein domains, especially in genes regulating the cytoskeleton.

ORGANISM(S): Mus musculus

PROVIDER: GSE76198 | GEO | 2016/08/25

SECONDARY ACCESSION(S): PRJNA306610

REPOSITORIES: GEO

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