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Discovery of Telomere Repeat-binding Zinc finger protein in the malaria parasite Plasmodium falciparum

ABSTRACT: ChIP-seq experiments were performed for the putative Telomere Repeat-binding Zinc finger protein (PfTRZ) in the malaria parasite Plasmodium falciparum strain 3D7. The gene encoding this factor (PF3D7_1209300) was endogenously tagged with either a GFP- or a 3xHA-tag and these transgenic parasite lines were used in ChIP-sequencing experiments. Sequencing of the ChIP and input libraries showed enrichment of PfTRZ at all telomere-repeat containing chromosome ends (reference genome Plasmodium falciparum 3D7 from PlasmoDB version 6.1) as well as in all upsB var promoters.In addition,PfTRZ was enriched at seven additional, intra-chromosomal sites and called in the PfTRZ-HA ChIP-seq only.

ORGANISM(S): Plasmodium falciparum

PROVIDER: GSE76537 | GEO | 2016/07/15

SECONDARY ACCESSION(S): PRJNA307665

REPOSITORIES: GEO

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Discovery of telomere repeat-binding factor in the malaria parasite Plasmodium falciparum

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