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Overexpression of Crumbs3/CRB3 in human mammary epithelial line MCF-10A

ABSTRACT: Our data demonstrate that overexpression of the polarity protein Crb3 elicits changes in MCF-10A cells that culminate in an increase in the release of amphiregulin (AR) and the subsequent activation of EGFR signaling to drive proliferation. Microarray analysis was performed to define global changes in the transcriptional landscape induced by Crb3. Results provide insight into a FERM domain protein (EBP41L4B) required for Crb3 mediated induction of proliferation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE76610 | GEO | 2018/12/26

REPOSITORIES: GEO

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