Transcriptomics

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Global gene expression profiling of Jmjd6- and Jmjd4-depleted mouse NIH3T3 fibroblasts


ABSTRACT: Emerging evidence suggests Jumonji domain-containing proteins are epigenetic regulators in diverse biological processes including cellular differentiation and proliferation. RNA interference-based analyses combined with gene expression profiling can effectively characterize the cellular functions of these enzymes. We found that the depletion of Jumonji domain-containing protein 6 (Jmjd6) and its paralog protein Jumonji domain-containing protein 4 (Jmjd4) individually by small hairpin RNAs (shRNAs) slowed cell proliferation of mouse NIH3T3 fibroblasts. We subsequently performed gene expression profiling on both Jmjd6- and Jmjd4-depleted mouse NIH3T3 fibroblasts using the Affymetrix GeneChip Mouse Exon 1.0 ST Array.

ORGANISM(S): Mus musculus

PROVIDER: GSE76758 | GEO | 2016/01/12

SECONDARY ACCESSION(S): PRJNA308504

REPOSITORIES: GEO

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