Transcriptomics

Dataset Information

0

MST-312: a telomerase inhibitor effectively blocking MYC oncogenic functions [array]


ABSTRACT: Reactivation of the telomerase reverse transcriptase subunit, TERT, is linked to tumourigenesis due to well-documented telomere-dependent and independent functions. The aim of this study was to investigate the effect of the telomerase inhibitor, MST-312, on TERT functions, focusing in particular, on its effects on MYC stabilty and MYC-regulated pathways, in order to assess its potential as a therapeutic agent. We demonstrate that MST-312 reduces MYC levels in cancer cells, leading to reduced MYC levels on chromatin, and subsequently affecting the MYC-regulated transcriptional program. As a result, MST-312 treatment increases the survival of lymphoma-bearing mice. Mechanistically, MST-312 affects the conformation of TERT, leading to TERT/Terc dissociation, and the subsequent loss of both its telomere-dependent and independent functions. Based on the presented data, we conclude that MST-312 treatment is a promising therapeutic strategy, in particular, in MYC-driven tumorus.

ORGANISM(S): Homo sapiens

PROVIDER: GSE77014 | GEO | 2020/01/01

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2020-01-01 | GSE77061 | GEO
| PRJNA309377 | ENA
2021-06-24 | GSE175994 | GEO
2012-11-26 | E-GEOD-41100 | biostudies-arrayexpress
| PRJNA309283 | ENA
| PRJNA309378 | ENA
2012-11-26 | GSE41100 | GEO
2015-04-23 | E-GEOD-60223 | biostudies-arrayexpress
2015-04-23 | E-GEOD-60175 | biostudies-arrayexpress
2015-04-23 | GSE60223 | GEO