Transcriptomics

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Development of gene signatures of human unipotent megakaryocyte progenitor and other hematopoietic stem and progenitor populations


ABSTRACT: We newly identified prospectively-isolatable unipotent megakaryocyte progenitor population (MegP) as the major source of megakaryocytes, which emerges directly from early stage of hematopoiesis bypassing megakaryocyte-erythroid lineage bifurcation and contributes to physiological and pathological human megakaryopoiesis. To explore gene expression signature of hematopoietic stem/progenitor populrations miroarry-based whole transcriptome analysis was performed. As a result, gene expression signature of MegP clearly reflected its differentiation potential.

ORGANISM(S): Homo sapiens

PROVIDER: GSE77439 | GEO | 2016/02/02

SECONDARY ACCESSION(S): PRJNA310336

REPOSITORIES: GEO

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