Expression array of early postnatal Mt1-mmp-targeted mammary glands
Ontology highlight
ABSTRACT: Mammary gland branching morphogenesis is thought to depend on the mobilization of the membrane-anchored matrix metalloproteinases, MT1-MMP and MT2-MMP, that drive epithelial cell invasion by remodeling the extracellular matrix and triggering associated signaling cascades. However, the roles that these proteinases play during mammary gland development in vivo remains undefined. A mammary gland branching program that occurs during the first 10 days of early postnatal development was used to characterize the impact of global Mt1-mmp or Mt2-mmp targeting on mammary gland morphogenesis. Transcriptome profiling of ductal networks and associated stroma was used to investigate the functional roles of MT1-MMP in the early postnatal mammary gland in an unbiased fashion.
ORGANISM(S): Mus musculus
PROVIDER: GSE77677 | GEO | 2016/10/05
SECONDARY ACCESSION(S): PRJNA311199
REPOSITORIES: GEO
ACCESS DATA