Transcriptomics

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Identification of genes that may predict response to azacitidine treatment.


ABSTRACT: Azacitidine (AZA) is a hypomethylating drug used to treat disorders associated with myelodysplasia and related neoplasms. Approximately 50% of patients do not respond to AZA and have very poor outcomes. It is of great interest to identify predictive biomarkers for AZA responsiveness. Therefore, we searched for specific genes whose expression level was associated with response status.Using microarrays, we analyzed gene expression patterns in bone marrow CD34+ cells from 32 patients with myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia with myelodysplasia-related changes before AZA therapy.

ORGANISM(S): Homo sapiens

PROVIDER: GSE77750 | GEO | 2016/02/10

SECONDARY ACCESSION(S): PRJNA311355

REPOSITORIES: GEO

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