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DNA methylation profiling of whole blood and reconstructed mixtures of purified leukocytes isolated from human adult blood

ABSTRACT: Confounding due to cellular heterogeneity represents one of the foremost challenges currently facing Epigenome-Wide Association Studies (EWAS). Statistical methods leveraging the tissue-specificity of DNA methylation for deconvoluting the cellular mixture of heterogeneous biospecimens such as whole blood, offer a promising solution. However, their performance depends entirely on the library of DNA methylation markers being used as the basis for deconvolution. The objective of this study was to train and validate an algorithm for the identification of optimal DNA methylation libraries for the deconvolution of adult human whole blood.

ORGANISM(S): Homo sapiens

PROVIDER: GSE77797 | GEO | 2016/02/12

SECONDARY ACCESSION(S): PRJNA311630

REPOSITORIES: GEO

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