Transcriptomics

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Trancriptome study of zebrafish mutant fn10a


ABSTRACT: We conducted functional analysis on zebrafish mutant fn10a by polyA+, 100bp paired end, strand-specific RNA-seq. By comparing the transcriptome of fn10a mutants and their wildtype siblings or wildtype controls, we revealed a transcriptome-wide RNA splicing deficiency and a large amount of intron-retaining transcripts, which resulted in compromised nonsense-mediated RNA decay and activation of the p53 pathway in fn10a mutants. 2 biological replicates were performed to consolidate the findings. We also conducted subcellular RNA-seq between fn10a mutants and wildtype siblings, to investigate the localization of intron retaining transcripts.

ORGANISM(S): Danio rerio

PROVIDER: GSE78106 | GEO | 2017/02/10

SECONDARY ACCESSION(S): PRJNA312615

REPOSITORIES: GEO

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