Silencing of GATA3 defines a novel stem cell like subgroup of ETP-ALL
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ABSTRACT: Genome wide expression profiling was used to detect cases of adult T-ALL lacking GATA3 expression. GATA3low T-ALL exhibited enrichment of myeloid/lymphoid progenitor (MLP) and granulocyte/monocyte progenitor (GMP) genes, while T-cell specific signatures were downregulated. Among upregulated genes FLT3 was identified and mutational analyses revealed a high rate of FLT3 mutations.
ORGANISM(S): Homo sapiens
PROVIDER: GSE78132 | GEO | 2016/02/26
SECONDARY ACCESSION(S): PRJNA313225
REPOSITORIES: GEO
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