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Gene Expression Profiling of Resting and Activated CD4+ T Cells in Patients with Multiple Sclerosis

ABSTRACT: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system with varying disease course as well as response to treatment. Thus, biomarkers for personalized treatment are highly needed. We tested the hypothesis that in vitro activation of CD4+ T cells from MS patients could reveal pathways containing potential biomarkers and found a dysregulated dynamic gene response upon activation. By integrating our findings with data from genome-wide association studies and using a network-based approach, we constructed a highly connected MS gene module disclosing cell activation and chemotaxis as central components.

ORGANISM(S): Homo sapiens

PROVIDER: GSE78244 | GEO | 2016/09/13

SECONDARY ACCESSION(S): PRJNA313022

REPOSITORIES: GEO

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