Transcriptomics

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Expression data of HDAC3-deficient and sufficient medullary thymic epithelial cells (mTECs)


ABSTRACT: Medullary thymic epithelial cells play essential role for induction of central self-tolerance by facilitating negative selection of self-reactive thymocytes and the generation of Foxp3+ regulatory T cells. Although studies highlighted the non-canonical NFκB pathway as the key regulator of mTEC development, comprehensive understanding of the molecular pathways regulating this process still remains incomplete. The aim of this study was to analyze the impact of Histone deacetylase 3 (HDAC3), which is highly expressed by mTECs, on mTEC development and function. We used Affymetrix mouse 1ST arrays to analyze the impact of the Hdac3 gene on the gene expression profile of MHC-II medullary thymic epithelial cells

ORGANISM(S): Mus musculus

PROVIDER: GSE78283 | GEO | 2016/04/01

SECONDARY ACCESSION(S): PRJNA313087

REPOSITORIES: GEO

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