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Response of Cupriavidus metallidurans CH34 to different Pt-species

ABSTRACT: Response of Cupriavidus metallidurans CH34 to cisplatin, Pt(IV)chloride and Au-NP

ORGANISM(S): Cupriavidus metallidurans CH34

PROVIDER: GSE78723 | GEO | 2016/02/27

SECONDARY ACCESSION(S): PRJNA313320

REPOSITORIES: GEO

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Response of Cupriavidus metallidurans CH34 to different Pt-species

Project description:Response of Cupriavidus metallidurans CH34 to cisplatin, Pt(IV)chloride and Au-NP In this study 7 different treatments were performed (first 2 as 3 replicates) to acquire expression profiles of the total genome of Cupriavidus metallidurans

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Project description:Whole-genome expression microarray experiments were conducted to assess the response of C. metallidurans CH34 to aqueous Au(III)-chloride and identify possible biochemical pathways for Au detoxification. Four microarray experiments were conducted to assess gold response at low, medium and high Au(III)-chloride concentrations (i.e., 10, 50 and 100 µM Au(III)-chloride) and different induction times (10 and 30 minutes with 50 µM Au(III)-chloride). Based on these arrays, the differentially expressed genes upon gold-exposure can be identified.

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