MRNA microarray in MCAo rat model with IV-hUMSC
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ABSTRACT:
ORGANISM(S): Rattus norvegicus
PROVIDER: GSE78731 | GEO | 2017/03/01
SECONDARY ACCESSION(S): PRJNA313417
REPOSITORIES: GEO
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Project description:We employed DNA microarray to identify genes differentially regulated by salidroside in ischemic brain of MCAO rats. With a cut of p < .01 and 2-fold change, we found that 121 genes were upregulated and 142 genes were down-regulated in the MCAO group, compared to the sham group. Administration of salidroside (1 h after reperfusion, daily for 6 d) enhanced 28 transcripts and suppressed 16 transcripts. The genes involved in neuroplasticity and oxygen carrier were further confirmed by qRT-PCR. Our data suggest that salidroside could regulate neuroplasticity in post-ischemic stroke, in addition to its neuroportective function.
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