Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genetic dissection of the α-globin super-enhancer

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE78835 | GEO | 2016/06/02

SECONDARY ACCESSION(S): PRJNA314091

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Genetic dissection of the Î±-globin super-enhancer

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-06-02 | E-GEOD-78835 | biostudies-arrayexpress

Genetic dissection of the α-globin super-enhancer in vivo.

Project description:Many genes determining cell identity are regulated by clusters of Mediator-bound enhancer elements collectively referred to as super-enhancers. These super-enhancers have been proposed to manifest higher-order properties important in development and disease. Here we report a comprehensive functional dissection of one of the strongest putative super-enhancers in erythroid cells. By generating a series of mouse models, deleting each of the five regulatory elements of the α-globin super-enhancer individually and in informative combinations, we demonstrate that each constituent enhancer seems to act independently and in an additive fashion with respect to hematological phenotype, gene expression, chromatin structure and chromosome conformation, without clear evidence of synergistic or higher-order effects. Our study highlights the importance of functional genetic analyses for the identification of new concepts in transcriptional regulation.

| S-EPMC5058437 | biostudies-literature

Genetic dissection of a super enhancer controlling the Nppa-Nppb cluster in the heart

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-07-30 | GSE158735 | GEO

Genetic dissection of the α-globin super-enhancer

Project description:Genetic dissection of the α-globin super-enhancer

| PRJNA314091 | ENA