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Effective Detection of Variation in Single Cell Transcriptome using MATQ-seq

ABSTRACT: We report here a new single-cell RNA-seq assay, Multiple Annealing and dC-Tailing based Quantitative single-cell RNA-seq (MATQ-seq), which provides the accuracy and sensitivity that enable the detection of transcriptional variations existing in single cells of the same type. We performed a systematic characterization of the technical noise using pool-and-split averaged single-cell samples and showed that the biological variations in single cells were observed with statistical significance.

ORGANISM(S): Homo sapiens

PROVIDER: GSE78968 | GEO | 2016/12/31

SECONDARY ACCESSION(S): PRJNA314523

REPOSITORIES: GEO

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