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Identification of genes and pathways regulated by epigenetic mechanisms in determining general intelligence (g) of inbred mice

ABSTRACT: General intelligence (g) is a common core shared by cognitive tasks. To study epigenetic regulation of “g”, 41 inbred mice raised under similar environmental conditions were subjected to five behavioral tests. We used principal component analysis to analyze 11 parameters that measure performance and reflect cognition of mice. Microarray gene expression analysis by using hippocampal RNAs of the 5, 12, and 8 mice consistently classified as having high, medium, and low cognition, respectively, by PC1 score and IQ score identified 17 genes that showed at least 1.3-fold difference in expression between mice with high and low cognition (FDR<0.30). Two of these genes were down-regulated and 15 of these genes were up-regulated in the high cognitive mice. Subsequent pathway-based analysis further identified gene-sets (GS) enriched in high cognitive mice and GS enriched in low cognitive mice. A number of genes implicated in our study have been previously associated with cognitive impairments. Our findings provide insights into genes and pathways regulated by epigenetic mechanisms in determining “g” and may shed lights on various disorders that affect cognitive function.

ORGANISM(S): Mus musculus

PROVIDER: GSE78981 | GEO | 2019/03/07

REPOSITORIES: GEO

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Identification of genes and pathways regulated by epigenetic mechanisms in determining general intelligence (g) of inbred mice

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