Transcriptomics

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Expression data from gemcitabine treated pancreatic CAFs


ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) has a characteristically dense stroma comprised predominantly of cancer associated fibroblasts (CAFs). CAFs promote tumor growth, metastasis and treatment resistance. We aimed to investigate the molecular changes and functional consequences associated with chemotherapy treatment of PDAC CAFs. Chemoresistant immortalized CAFs (R-CAFs) were generated by continuous incubation in 100nM gemcitabine. Gene expression differences between treatment naïve CAFs (N-CAFs) and R-CAFs were compared by array analysis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE78982 | GEO | 2016/03/09

SECONDARY ACCESSION(S): PRJNA314574

REPOSITORIES: GEO

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