Transcriptomics

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Recessive mutations in TRMT10C cause defects in mitochondrial RNA processing and multiple respiratory chain deficiencies


ABSTRACT: We investigated the changes in the abundance of reads across the entire mitochondrial transcriptome, we found an increase in the regions that span gene boundaries, where RNA processing is required to release individual mitochondrial RNAs from the precursor transcripts. These data confirm an impairment of mt-tRNA processing efficiency without severe effects on mature mt-mRNA or mt-tRNA steady-state levels. Strand-specific coverage profiles were generated in bedGraph format and normalised to library size (RPM; reads per million mapped).

ORGANISM(S): Homo sapiens

PROVIDER: GSE79120 | GEO | 2016/04/28

SECONDARY ACCESSION(S): PRJNA314985

REPOSITORIES: GEO

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