Transcriptomics

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Allele specific deletion of enhancer clusters within mouse F1 embryonic stem cells


ABSTRACT: We provide data from several targeted deletions of transcriptional enhancer clusters within mouse F1 embryonic stem (ES) cells.  We targeted these regions for deletion with CRISPR/Cas9 genome editing tools.  We demonstrate through heterozygous enhancer cluster deletion and  allele specific RNA-seq that enhancer clusters differ in their regulatory activity as the magnitude of the observed change in transcription upon enhancer cluster deletion varies greatly.

ORGANISM(S): Mus musculus

PROVIDER: GSE79313 | GEO | 2016/11/18

SECONDARY ACCESSION(S): PRJNA315451

REPOSITORIES: GEO

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