Allele specific deletion of enhancer clusters within mouse F1 embryonic stem cells
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ABSTRACT: We provide data from several targeted deletions of transcriptional enhancer clusters within mouse F1 embryonic stem (ES) cells. We targeted these regions for deletion with CRISPR/Cas9 genome editing tools. We demonstrate through heterozygous enhancer cluster deletion and allele specific RNA-seq that enhancer clusters differ in their regulatory activity as the magnitude of the observed change in transcription upon enhancer cluster deletion varies greatly.
ORGANISM(S): Mus musculus
PROVIDER: GSE79313 | GEO | 2016/11/18
SECONDARY ACCESSION(S): PRJNA315451
REPOSITORIES: GEO
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