Spatial intratumor heterogeneity of epigenetic alterations in esophageal squamous cell carcinoma
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ABSTRACT: Esophageal squamous cell carcinoma (ESCC) is among the most common malignancies, but little is known about the spatial intratumor heterogeneity (ITH) and the temporal clonal evolutionary processes in this cancer. Interestingly, the epigenetic profiling also showed strong evidence of spatial ITH, and the phyloepigenetic trees were extremely similar with the phylogenetic ones, indicating the interplay and co-dependency of genetic and epigenetic alterations in ESCC. We found that several genes were both mutated and hypermethylated at their promoters, such as ASXL1 and EPHA7. Our integrated investigations of the spatial ITH and the temporal clonal evolution might provide insights into developing biomarkers for early diagnosis of ESCC, as well as personalized therapeutic targets for treating this malignancy.
ORGANISM(S): Homo sapiens
PROVIDER: GSE79366 | GEO | 2016/08/20
SECONDARY ACCESSION(S): PRJNA315618
REPOSITORIES: GEO
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