Transcriptomics

Dataset Information

0

Gene expression patterns within cell lines are predictive of chemosensitivity


ABSTRACT: We generated RNA's and measured expression of 40000 genes using spotted cDNA microarrays from the fifty nine publicly available cell lines of the NCI Developmental Therapeutics Program's NCI60 studies and an additional set of seven cell lines for which GI50 compound sensitivity data were available. All cell lines were grown to 80% confluence in RPMI 1640 supplemented with phenol red, glutamine (2 mM) and 5% fetal calf serum. This expression data, in conjunction with the compound sensitivity data sets available from the DTP, were used to empirically determine whether gene-compound correlates of a sufficiently high correlation coefficient would have a suitable low false discovery rate to support the use of a correlative approach and these datasets for early discovery approaches for new targeted therapies. A cell type comparison design experiment design type compares cells of different type for example different cell lines. Keywords: cell type comparison design

ORGANISM(S): Homo sapiens

PROVIDER: GSE7947 | GEO | 2008/02/08

SECONDARY ACCESSION(S): PRJNA100125

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2008-02-07 | E-GEOD-7947 | biostudies-arrayexpress
2013-03-01 | GSE42944 | GEO
2008-01-01 | GSE7505 | GEO
2013-03-01 | E-GEOD-42944 | biostudies-arrayexpress
2010-05-27 | E-GEOD-7505 | biostudies-arrayexpress
2005-07-02 | GSE2520 | GEO
| PRJNA100479 | ENA
2016-06-29 | E-GEOD-80332 | biostudies-arrayexpress
2015-02-20 | GSE40239 | GEO
2006-01-25 | GSE4089 | GEO