Genomics

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TRF2 is recruited to the pre-initiation complex as a testis-specific subunit of TFIIA/ ALF to promote haploid cell gene expression [ChIP-seq]


ABSTRACT: TRF2 is a paralogue of TATA-box binding protein (TBP) with highest expression in testis. Although Trf2 inactivation in mice leads to arrested spermatogenesis, there is no direct evidence that Trf2 is recruited to chromatin to directly regulate gene expression. We used genetically modified mice where endogenous Trf2 has been modified to carry a TAP-TAG to perform ChIP-reChIP followed by deep sequencing. We found that Trf2 is recruited to all active promoters as a subunit of TFIIA/ALF complex together with TBP.

ORGANISM(S): Mus musculus

PROVIDER: GSE79601 | GEO | 2016/08/31

SECONDARY ACCESSION(S): PRJNA316630

REPOSITORIES: GEO

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