Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Toxoplasma gondii remodels the cis-regulatory landscape of infected human host cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE79612 | GEO | 2017/03/08

SECONDARY ACCESSION(S): PRJNA316435

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Toxoplasma gondii remodels the cis-regulatory landscape of infected human host cells [HELP-tagging]

Project description:To study the host DNA methylome of human fibroblasts after infection with T. gondii (Type I-RH).

2017-03-08 | GSE79610 | GEO

Toxoplasma gondii remodels the cis-regulatory landscape of infected human host cells [ATAC-seq]

Project description:To identify the open chromatin cis-regulatory elements present in uninfected and T. gondii (Type I-RH) infected HFFs.

2017-03-08 | GSE79609 | GEO

Toxoplasma gondii remodels the cis-regulatory landscape of infected human host cells [RNA-seq]

Project description:To study the host transcriptome of human fibroblasts after infection with T. gondii (Type I-RH).

2017-03-08 | GSE79608 | GEO

Toxoplasma gondii remodels the cis-regulatory landscape of infected human host cells [HELP-GT]

Project description:To study the host DNA hydroxymethylome of human fibroblasts after infection with T. gondii (Type I-RH).

2017-03-08 | GSE79611 | GEO

Toxoplasma gondii remodels the cis-regulatory landscape of infected human host cells

Project description:Toxoplasma gondii remodels the cis-regulatory landscape of infected human host cells

| PRJNA316435 | ENA

Toxoplasma gondii actively remodels the microtubule network in host cells.

Project description:Toxoplasma gondii infection triggers host microtubule rearrangement and organelle recruitment around the parasite vacuole. Factors affecting initial stages of microtubule remodeling are unknown. To illuminate the mechanism, we tested the hypothesis that the parasite actively remodels host microtubules. Utilizing heat-killed parasites and time-lapse analysis, we determined microtubule rearrangement requires living parasites and is time dependent. We discovered a novel aster of microtubules (MTs) associates with the vacuole within 1h of infection. This aster lacks the concentrated foci of gamma (gamma)-tubulin normally associated with MT nucleation sites. Unexpectedly, vacuole enlargement does not correlate with an increase in MT staining around the vacuole. We conclude microtubule remodeling does not result from steric constraints. Using nocodazole washout studies, we demonstrate the vacuole nucleates host microtubule growth in-vivo via gamma-tubulin-associated sites. Moreover, superinfected host cells display multiple gamma-tubulin foci. Microtubule dynamics are critical for cell cycle control in uninfected cells. Using non-confluent monolayers, we show host cells commonly fail to finish cytokinesis resulting in larger, multinucleated cells. Our data suggest intimate interactions between T. gondii and host microtubules result in suppression of cell division and/or cause a mitotic defect, thus providing a larger space for parasite duplication.

| S-EPMC2765197 | biostudies-literature

Expression data from host cells infected with different strains of Toxoplasma gondii

Project description:This SuperSeries is composed of the SubSeries listed below.

2011-01-10 | GSE25476 | GEO

Toxoplasma gondii bradyzoites manipulate host cell transcription

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-01-15 | GSE125122 | GEO

Expression data from chicken embryonic fibroblasts infected with Toxoplasma gondii

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2011-05-27 | E-GEOD-29565 | biostudies-arrayexpress

Human foreskin fibroblasts (HFFs) infected with type I strains of Toxoplasma gondii

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series