Overexpression of LMO2 causes aberrant human T-cell development in vivo by three potentially distinct cellular mechanisms
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ABSTRACT: LMO2 overexpressing transgenic mouse models suggest an accumulation of immature T-cell progenitors in the thymus as main pre-leukemic event. The effects of LMO2 overexpression on human T-cell development in vivo, however, are unknown. Here we report studies of a humanized mouse model transplanted with LMO2 transduced human hematopoietic stem and progenitor cells. The effects of LMO2 overexpression were confined to the T-cell lineage although initially multipotent cells were transduced. Three effects of LMO2 on human T-cell development were observed: 1) a block at the DN/ISP stage, 2) an accumulation of CD4+CD8+ double positive CD3- cells and 3) an altered CD8/CD4 ratio with enhanced peripheral T lymphocytes
ORGANISM(S): Homo sapiens
PROVIDER: GSE79625 | GEO | 2016/03/26
SECONDARY ACCESSION(S): PRJNA316470
REPOSITORIES: GEO
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