Transcriptomics

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HDAC-42 modulates acid-induced gene expression in human SEG-1 esophageal adenocarcinoma cells


ABSTRACT: The role of acid and bile salts in the pathogenesis of esophageal carcinoma arising from Barrett's metaplasia has been well established. Cell proliferation of Barrett's epithelium in response to pulsatile acid exposure has since been confirmed in vivo using endoscopy specimens. Histone deactylases (HDACs) modulate nucleosomal packaging of DNA, thereby influencing gene transcription and multiple cancer-associated processes. Thus, we conducted microarray analysis to assess the ability of HDAC-42 to modulate key acid-induced changes as well as to impact other genes altered as the normal esophageal epithelium progresses along the metaplasia-dysplasia-esophageal adenocarcinoma continuum. Keywords: acid-pulsed cells pretreated with HDAC inhibitor or vehicle

ORGANISM(S): Homo sapiens

PROVIDER: GSE7964 | GEO | 2007/07/30

SECONDARY ACCESSION(S): PRJNA100715

REPOSITORIES: GEO

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