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Comparison of gene expression of memory B cells subpopulations

ABSTRACT: We investigated the ability of monoclonal B cells to restore primary and secondary antibody responses in adoptive immune-deficient hosts. Priming induced B cell activation and expansion, AID expression, antibody production and the generation of IgM+IgG- and IgM-IgG+ antigen-experienced B-cell subsets that persisted in the lymphopenic environment by cell division. Using RNA sequencing, we compared the gene expression profil of memory B cells subpopulations and activated B cells. These data showed a clear discrimination of naïve and activated/memory cells while indicating only minor differences between both subsets of memory cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE79672 | GEO | 2016/11/13

SECONDARY ACCESSION(S): PRJNA316675

REPOSITORIES: GEO

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