Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA sequencing for identifying downstream targets of miR25/93

ABSTRACT: we identify several downstream targets that are under control of miR25/93 cluster

ORGANISM(S): Homo sapiens

PROVIDER: GSE79788 | GEO | 2018/02/06

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Identifying hand2 downstream targets in cardiomyocyte during early cardiogenesis

Project description:Identifying hand2 downstream targets in cardiomyocyte during early cardiogenesis

| PRJNA1010830 | ENA

Identification of miR-154 downstream targets

Project description:Identification of miR-154 downstream targets

| PRJNA593019 | ENA

miR-93 Targets in Human Endothelial Cells

Project description:miR-93-5p controls endothelial glycolysis and proliferation

2017-11-01 | GSE86497 | GEO

Altered expression and Downstream targets of uc.323

Project description:Altered expression and Downstream targets of uc.323

| PRJNA592899 | ENA

Downstream targets of uc.323-mediated cardiomyocyte hypertrophy

Project description:Downstream targets of uc.323-mediated cardiomyocyte hypertrophy

| PRJNA592523 | ENA

NRF2 Controls Endothelial Plasticity with miR-93

Project description:Here we studied the role of oxidized phospholipids in mediating phenotype switching of endothelial cells between quiescent and angiogenic states. Two oxPAPC datasets, a microRNA array and global run-on sequencing (GRO-seq), was combined with Nuclear factor erythroid 2-Related Factor 2 (NRF2) binding model to select candidate miRNAs for further studies. The pre-screening resulted in a selection of miR-106b~25 cluster for further studies. The cluster was shown to be both oxPAPC-responsive and NRF2-regulated, and its diagnostic and prognostic potential was investigated in pericardial fluid samples of heart failure and atherosclerosis patients. As the most abundant member of the cluster in both endothelial cells and pericardial fluid of atherosclerosis patients, miR-93-5p was selected for more detailed studies. RNA-seq from miR-93 overexpressing cells revealed significant changes in pathways related to angiogenesis. Together with NRF2, miR-93 was shown to control endothelial plasticity through regulation of the key players, namely Krüppel-like factor 2 (KLF2) for quiescence, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) for glycolysis, and Vascular Endothelial Growth Factor A (VEGFA), Forkhead box protein O1 (FOXO1) and MYC proto-oncogene protein (MYC) for growth and proliferation.The findings show that NRF2 and miR-93 control the activity of endothelial cells and mediate the effects of oxPAPC on endothelial activation, collectively providing novel mechanisms for the control of endothelial plasticity and oxPAPC response.

2017-11-01 | GSE103530 | GEO

Identification of STAT3 downstream targets involved in chemoradiotherapy resistance

Project description:Identification of STAT3 downstream targets involved in chemoradiotherapy resistance

| PRJNA579909 | ENA

Robust partitioning of microRNA targets from downstream regulatory changes

Project description:Robust partitioning of microRNA targets from downstream regulatory changes

| PRJNA589374 | ENA

Downstream targets of ATR in CIN612 HPV-positive cells

Project description:Downstream targets of ATR in CIN612 HPV-positive cells

| PRJNA597129 | ENA

The identification of Dwg downstream targets using ChIP-seq

Project description:The identification of Dwg downstream targets using ChIP-seq