Transcriptomics

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Human glioblastoma-associated microglia/monocytes express a distinct RNA profile compared to human control and murine samples


ABSTRACT: We used RNA sequencing to compare the expression profile of 8 CD11b+ human glioblastoma-associated microglia/monocytes (hGAMs) samples to 8 human non-tumor CD11b+ microglia samples. Hierarchical clustering and principal component analysis showed a clear separation of the two sample groups and we identified 334 significantly regulated genes in hGAMs. In comparison to human control microglia hGAMs up-regulate genes associated with mitotic cell cycle, cell migration, cell adhesion, and extracellular matrix organization.

ORGANISM(S): Homo sapiens

PROVIDER: GSE80338 | GEO | 2016/06/19

REPOSITORIES: GEO

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