Transcriptomics

Dataset Information

0

A splicing switch of TEAD4 regulates Hippo-YAP signaling pathway to inhibit tumor proliferation


ABSTRACT: Splicing dysregulations extensively occur in cancers, yet the biological consequences of such alterations are mostly undefined. Here we report that the Hippo-YAP signaling, a key pathway that regulates cell proliferation and organ size, is under control of a new splicing switch. We show that TEAD4, the transcription factor that mediates Hippo-YAP signaling, undergoes alternative splicing facilitated by the tumor suppressor RBM4, producing a truncated isoform, TEAD4-S, which lacks N-terminal DNA-binding domain but maintains YAP-interaction domain. TEAD4-S is located in both nucleus and cytoplasm, acting as a dominant negative isoform to YAP activity. Consistently, TEAD4-S is reduced in cancer cells, and its re-expression suppresses cancer cell proliferation and migration, inhibiting tumor growth in xenograft mouse model. Furthermore, TEAD4-S is reduced in human cancers, and patients with elevated TEAD4-S levels have improved survival. Altogether these data reveal a novel RBM4-mediated splicing switch that serves to fine-tune Hippo-YAP pathway.

ORGANISM(S): Homo sapiens

PROVIDER: GSE80372 | GEO | 2016/06/16

SECONDARY ACCESSION(S): PRJNA318757

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2016-06-16 | E-GEOD-80372 | biostudies-arrayexpress
| OEX000086 | NODE
| OEX000084 | NODE
2024-07-15 | GSE237418 | GEO
2016-02-11 | E-GEOD-73396 | biostudies-arrayexpress
| PRJNA318757 | ENA
2022-08-31 | E-MTAB-10744 | biostudies-arrayexpress
| PRJNA604980 | ENA
2011-08-21 | E-GEOD-29208 | biostudies-arrayexpress
2024-05-31 | GSE252142 | GEO