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Astrocyte-specific transcriptional response to glucocorticoid receptor activation in the central nervous system

ABSTRACT: Many studies indicated in an indirect way that astrocytes are a major target for transcriptional responses induced by glucocorticoids in the CNS, implying that glial cells an important consituent of stress responses. To address this issue directly we have generated astrocyte-specific conditional GR knockout mice (Cx30GRko) using Cre/loxP system utilizing connexin 30 promoter driving expression of CreERT2 recombinase. Genome wide analysis of molecular effects of astrocytic GR knockout would allow for dissecting the glial cell-type specific components of stress response mediated by glucocorticoids

ORGANISM(S): Mus musculus

PROVIDER: GSE80504 | GEO | 2017/01/01

SECONDARY ACCESSION(S): PRJNA319150

REPOSITORIES: GEO

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