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Etv inactivation effect on embryonic lung development

ABSTRACT: ETV4 and ETV5 are FGF-activated transcription factor genes. Inactivation of Etv4 and Etv5 in the lung epithelium led to prolonged branch tip growth and delayed new branch formation. We used microarrays to detail the global programme of gene expression in embryonic day 13.5 mouse lungs and identified distinct classes of dysregulated genes affect by Etv4;5 epithelial specific knockout.

ORGANISM(S): Mus musculus

PROVIDER: GSE80734 | GEO | 2016/04/28

SECONDARY ACCESSION(S): PRJNA319836

REPOSITORIES: GEO

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RNASeq to investigate ETV4 and ETV5 function in human foetal lung tip progenitor cells

Project description:In order to understand transcription factor ETV4 and ETV5 function, we have knocked down ETV4 and ETV5 synergistically in human foetal lung tip progenitor organoids using an inducible CRISPRi system. We discovered that ETV double knockdown led to organoid cell self-renewal defects

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E3 ubiquitin ligase Rfwd2 inactivation effect on embryonic lung development

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Transcription profiling of mouse knockouts for Etv4 and Etv5 - plusGDNF and minusGDNF comparison using U74Av2 and 430A arrays

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