Transcriptional response to intracellular DNA in cells lacking AIM2-like receptors

ABSTRACT: Analysis of ALR-deficient cells indicates that ALRs are not required for the IFN response to intracellular DNA. To explore whether AIM2-like receptors activated another innate signaling pathway upon DNA detection, we performed microarray analysis comparing ALR+/+, ALR-/-, and AIM2-/- macrophages and fibroblasts 4 or 8 hours after transfection with calf-thymus DNA.

ORGANISM(S): Mus musculus

PROVIDER: GSE80766 | GEO | 2016/05/31

SECONDARY ACCESSION(S): PRJNA319953

REPOSITORIES: GEO