Functional coordination of alternative splicing in the mammalian central nervous system
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ABSTRACT: Using a quantitative alternative splicing (AS) microarray platform, we have identified a large number of widely-expressed mouse genes containing single or coordinated-pairs of alternative exons that are spliced in a tissue-regulated fashion. The majority of these AS events display differential regulation in central nervous system (CNS) tissues. Approximately half of the corresponding genes have neural-specific functions and operate in common processes and interconnected pathways. Differential regulation of AS in the CNS tissues correlates strongly with a set of mostly new motifs that are predominantly located in the intron and constitutive exon sequences neighboring CNS-regulated alternative exons. Different subsets of these motifs are correlated with either increased inclusion or increased exclusion of alternative exons in CNS-tissues, relative to the other profiled tissues. Keywords: Alternative splicing
ORGANISM(S): Mus musculus
PROVIDER: GSE8081 | GEO | 2007/08/01
SECONDARY ACCESSION(S): PRJNA100919
REPOSITORIES: GEO
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