Transcriptomics

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IL-2 therapy restores regulatory T cell dysfunction induced by calcineurin inhibitors


ABSTRACT: CNIs drastically modify the Treg specific transcriptional program in vivo in an IL-2 dependent manner CD4+CD25+FOXP3+ regulatory T cells (Tregs) constitute a heterogeneous lymphocyte subpopulation essential for establishing peripheral immune tolerance. Interleukin-2 (IL-2) plays a critical role in maintaining immune homeostasis promoting optimal development, survival and function of Tregs. Because of their suppressive properties, manipulation of Tregs represents a clear target to modulate immune responses in transplantation and autoimmunity. However, the specific effects of adjunctive immunosuppressive drugs to the maintenance and function of the different Treg subsets remain unclear. Calcineurin inhibitors (CNIs), which are the mainstay immunosuppressants in transplantation, are the most effective agents in controlling alloreactive effector T cells, but also hamper Treg activity. In this study we sought to investigate the differential effects of CNIs on the homeostasis of Treg subsets, and the extent to which these effects are dependent on the overall availability of IL-2.

ORGANISM(S): Mus musculus

PROVIDER: GSE80814 | GEO | 2017/05/24

SECONDARY ACCESSION(S): PRJNA320061

REPOSITORIES: GEO

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