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Hippocampal gene expression signature following inflammation in epileptic mice

ABSTRACT: We used a systemic inflammatory challenge in animals with chronic mesial temporal lobe epilepsy to identify novel molecular pathways involved in seizure regulation. Mice were first rendered epileptic by a single intrahippocampal injection of kainic acid (KA). After a period of two-three weeks, mice developed spontaneous seizures and then received a single intraperitoneal injection of lipopolysaccharide (LPS) to mimic systemic inflammation, or saline as a control. Gene expression analysis by microarrays was then performed on hippocampal RNA samples extracted 4 and 24 hours after LPS or saline treatment (n=3 samples per treatment group).

ORGANISM(S): Mus musculus

PROVIDER: GSE81024 | GEO | 2016/05/03

SECONDARY ACCESSION(S): PRJNA320299

REPOSITORIES: GEO

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